Pathogenesis of Intestinal Amebiasis: From Molecules to Disease
نویسندگان
چکیده
منابع مشابه
Pathogenesis of intestinal amebiasis: from molecules to disease.
In spite of a wealth of knowledge on the biochemistry and cellular and molecular biology of Entamoeba histolytica, little has been done to apply these advances to our understanding of the lesions observed in patients with intestinal amebiasis. In this review, the pathological and histological findings in acute amebic colitis are related to the molecular mechanisms of E. histolytica pathogenicit...
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Entamoeba histolytica is an invasive enteric protozoan parasite that causes amebiasis. Globally, diarrheal disease is second only to pneumonia as a leading cause of death in children under five, and intestinal amebiasis is one of the top ten causes of severe diarrhea in the developing world. Amebiasis is more common in malnourished children, a state that afflicts approximately onethird of child...
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Amebiasis is a major cause of morbidity and mortality throughout the tropical world. Entamoeba histolytica is now recognized as a separate species from the morphologically identical E. dispar, which cannot invade. Cysteine proteinases are a key virulence factor of E. histolytica and play a role in intestinal invasion by degrading the extracellular matrix and circumventing the host immune respon...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2000
ISSN: 0893-8512
DOI: 10.1128/cmr.13.2.318-331.2000